Biology Question
Description
![](https://studysplash.blog/wp-content/uploads/2023/09/1_LFbl_ZPQ4lardjOyusC5Pg.jpeg)
Having Trouble Meeting Your Deadline?
Get your assignment on Biology Question completed on time. avoid delay and – ORDER NOW
Molecular target/Mechanism of action paper: After graduating, you join a medical group conducting basic and clinical research. Your boss says that the clinical staff and new students are sharp and motivated, but don’t understand the molecular target and mechanism of action of a key drug class very well. Seeing an opportunity, you volunteer to write a short review paper (~1200-1500 words and may include 1 or 2 pages of figures/tables/diagrams) or a Fact Sheet for your colleagues. You will also briefly describe how disruption of normal function can result in human diseases/disorders. Select a target/mechanism from a list to be provided or propose your own. Resources including primary literature and reviews will also be provided. You may write this in either the form of a) a traditional review paper or b) as a fact sheet (3 pages with diagrams/figures/tables related to text).
For a traditional review,
Write 1200-1500 words describing a molecular target or pathway following a journal format. May include Figures and Tables. Include three or more references.
For a fact sheet
3 Page Fact Sheet for Colleagues and Other Students on a molecular target or mechanism of action/pathway
For a molecular target review or fact sheet
Should include information from three or more references on:
1. Gene(s)
2. Protein(s)
3. Gene expression
4. Involvement in disease pathogenesis and/or pathophysiology
5. Description of a marketed medicine or drug.
For a mechanism of action review or fact sheet
Should include description of
1. Molecular structure and/or cellular pathway
2. Normal function and regulation of this pathway (i.e., no disease)
3. Changes in the mechanism or pathway that occur in one or more disease states
4. Any existing therapeutics that modulate this mechanism/pathway including there relative effectiveness (how well do they work) and safety (what types of safety issues are observed with this mechanism/pathway)
Examples of possible targets/pathways:
1. G-protein coupled receptors
Serotonin receptors – 5-HT1A, 5-HT!D, 5-HT2A, 5-HT2C, 5-HT-3, 5-HT4
Dopamine receptors – D1, D2, D3, D4, D5
metabotropic glutamate receptors – mGluR1, mGluR5, mGluR4, mGluR8
Calcium Sensing Receptor (CASR)
Glucagon-like peptide-1 receptor (GLP1R)
Melanocortin 4 receptor (MC4R)
Frizzled 1, 2, 3, 4, etc (Wnt Pathway)
2. Ion Channels
Ligand-gated Ionotropic Glutamate Receptors (iGluRs) – kainate, AMPA, NMDA
Ligand-gated Nicotinic Receptors – alpha 3-beta 4, alpha 7, alpha 6
Voltage gated Calcium channels (CaV) – L-type, N-type, T-type
Voltage gated Sodium channels (NaV) – TTX-sensitive, TTX-insensitive
3. Receptor Tyrosine Kinases
Epidermal growth factor receptor (EGFR)
Vascular Endothelial Growth Factor Receptor (VEGFR)
Insulin Receptors
4. Nuclear Hormone receptors
Estrogen receptors
Androgen receptors
Glucocorticoid receptors
LXR
PPAR
5. Pathways
MAP Kinase pathways
JAK/STAT pathways
Wnt pathway
Hippo
Sonic Hedgehog
Tumor necrosis factor (TNF) pathways
Apoptotic pathways & signaling – Bcl, BclX, BAX,
and many, many more!
and an example is attached below!
Our website has a team of professional writers who can help you write any of your homework. They will write your papers from scratch. We also have a team of editors just to make sure all papers are of HIGH QUALITY & PLAGIARISM FREE. To make an Order you only need to click Order Now and we will direct you to our Order Page at Litessays. Then fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Fill in all the assignment paper details that are required in the order form with the standard information being the page count, deadline, academic level and type of paper. It is advisable to have this information at hand so that you can quickly fill in the necessary information needed in the form for the essay writer to be immediately assigned to your writing project. Make payment for the custom essay order to enable us to assign a suitable writer to your order. Payments are made through Paypal on a secured billing page. Finally, sit back and relax.